Abstract
Summary
The specific activities of total liver protein and of the proteins of mitochondria, microsomes, and cell sap were higher in the protein-depleted rats than in the controls. Specific activities of these proteins in tumor-bearing rats, on the other hand, decreased below those in control animals. As the specific activity of the liver proteins of the tumor-bearing animals decreased, there was an increase in serum protein activity which then decreased as the tumor tissue continued to gain in isotopic activity. The data suggested that the protein-depleted animals had a decreased rate of synthesis of liver nuclear and serum albumin proteins. The data also indicated a rapid synthesis of nuclear protein in the tumors of tumor-bearing animals.
The author wishes to express appreciation to Miss Zina Sapankevych and Mr. Albert Schnerring who assisted in various phases of this study.
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