Abstract
Summary
During incubation of tyramie with rabbit aorta or stomach muscle, tyramine is metabolized as evidenced by a significant decrease in the amount of p-hydroxyphenyl and primary amine groups of tyramine and by concomitant changes in the ultraviolet absorption spectrum of the incubation mixture. Chromatographic analysis revealed the appearance of p-hydroxyphenylacetaldehyde and p-hydroxyphenylacetic acid as well as 5 unknown phenolic spots. One of these spots has been tentatively identified as 3.4-dihydroxyphenylacetic acid. The decrease of p-hydroxyphenyl groups of tyramine is probably accounted for by its conversion to dihydroxy or β-hydroxy compounds which given less color in the analytical procedure used.
The author wishes to thank Dr. Robert F. Furchgott for his interest and encouragement during this investigation.
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