Abstract
Summary
Rats with nephrosis induced by treatment with aminonucleoside showed an increased susceptibility to pyelonephritis when challenged with Escherichia coli. The incidence of pyelonephritic lesions, determined histologically, was significantly greater in these animals than in rats injected with E. coli only. The organisms were gradually removed from the normal kidney and were no longer demonstrable by culture 30 days after injection. In contrast, at 30 days, significant numbers of E. coli were still present in the kidneys of some rats with aminonucleo-side-induced nephrosis. It is suggested that functional vascular alterations or, possibly, changes in renal enzyme patterns may be the important factors in the pathogenesis of this type of pyelonephritis.
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