Passage of Thiopental and Barbital Into Ocular and Cerebrospinal Fluids of Dog. ∗

Abstract

Summary

Experiments with dogs have shown that thiopental enters ocular fluid and spinal fluid more rapidly than barbital does. This is probably due to the higher lipid solubility of the thio barbiturate.

The authors thank Drs. Bernard B. Brodie and J. J. Burns for helpful criticism.