Abstract
Summary
Rats exposed to 6 p.p.m. ozone by volume for 4 hours developed severe pulmonary edema and hemorrhage with significant increases in lung weight, lung protein content, and lung 5-HT when related to body weight. Ozone exposure was found to decrease MAO activity; this was an effect of dilution by edema rather than destruction of the enzyme. Ozone exposure did not alter blood 5-HT content. Possible mechanisms involved in the lung 5-HT increase after exposure to ozone were discussed briefly.
The authors appreciate 5-HT made available by Vismara Terapeutici, Casatenova Brianza, Italy, through California Corp. for Biochemical Research.
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