Abstract
Summary
The effect of Isuprel on MABP, CO and TPR has been investigated in the anesthetized dog in which the effect of the drug on HR is allowed to occur, as well as in the anesthetized dog in which electrically induced atrial or ventricular tachycardia is initiated before and maintained throughout period of action of the drug to prevent the increase in heart rate normally induced by the drug. Under the circumstances of drug dosage, rate of the induced tachycardia as well as control values of HR and CO, the effect of the drug on CO and TPR is essentially the same, whether the effect of the drug on HR is permitted or prevented.
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