Abstract
Summary
Aspermatogenesis was induced in adult guinea pigs (1) by repeated intracutaneous injections of homologous testicular homogenate without adjuvant, and (2) by injection of testicular antigen and complete adjuvant in separate sites on the same side of the nuchal mid-line. With testicular tissue alone, severe germinal lesions were induced after 100 days in animals injected 3 or 6 times weekly with 0.1 or 0.05 ml, respectively. Degree of germinal damage resulting from separate-site injection of uncombined antigen and adjuvant was comparable to that when testis is incorporated into complete paraffin oil adjuvants prior to administration. Results of separate-site injections suggest dependency on a common lymphatic drainage system.
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