Abstract
Summary
The spinal cord was deviated from the tail into the rear limb of the lizard, Lygosoma. In those cases where the deviated cord retained its integrity and augmented the nerve complement of the limb, a limited regenerative response occurred. Therefore, the tissues of the limb are still capable of responding to the inductive influences of nerves. Histological examination of the regenerates revealed that they fulfilled the requirements of true limb regeneration. Experimental control limbs which underwent the same treatment with the exception that the cord was not deviated into them, failed to show a regenerative response. This study strongly suggests that lack of an adequate supply of nerve tissue imposes one, if not the major, restriction on limb regeneration in this lizard.
The author wishes to express his appreciation to Dr. Merle Mizell for encouragement and guidance during this study.
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