Abstract
Summary
Evidence is presented that endogenous trypsinogen in extracts of dog pancreas is activated under the same conditions that cathepsin B activates trypsinogen in vitro. The activation occurs at pH 3.6 and is enhanced by cysteine and is inhibited by iodoacetic acid. The tentative conclusion reached is that cathepsin B-like enzymes in pancreas are catalyzing the reaction. The possible clinical implications of such reactions is discussed.
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