Abstract
Summary
1. A mouse leukemia virus, originally isolated from spontaneous Ak leukemia, then passed serially through newborn mice (passage A), and consistently leukemogenic for suckling mice of susceptible strains, was found to be leukemogenic also for newborn rats. 2. Following intraperitoneal inoculation of passage A filtrates into newborn Sprague-Dawley rats, leukemia developed in from 57% to 73% of the inoculated animals, after a latency varying from 2 1/2 to 4 1/2 months. 3. Either localized thymic lymphosarcomas, or generalized lymphatic leukemia, involving also spleen, liver, and mesenteric lymph nodes, developed in the inoculated animals. A few rats developed acute stem-cell leukemia.
Get full access to this article
View all access options for this article.