Abstract
Summary
The distribution of AIB in vivo in diaphragm and gastrocnemius muscle of intact, hypophysectomized, and adrenalectomized rats has been examined with respect to the effect of insulin and epinephrine and corticoids. Adrenalectomy, but not hypophysectomy, impairs the ability of insulin to increase the accumulation of AIB in muscle to the level observed after insulin in intact rats. Epinephrine alone has slight effect on muscle AIB in adrenalectomized rats, but concurrent administration of epinephrine and insulin to adrenalectomized rats restores AIB distribution nearly to the level observed in adrenal-intact rats receiving insulin. Maintenance treatment of adrenalectomized rats with either DOC or cortisol resulted in normal AIB distributions in diaphragm and both corticoids, especially DOC, also enhance the AIB accumulation response to insulin. The suggestion emerges that these hormonal effects on AIB accumulation may be related to alterations in electrolyte metabolism.
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