Abstract
Summary
Acute reserpine treatment of guinea pigs, rats and human patients resulted in activation of the pituitary-adrenal cortex axis demonstrated by hypertrophy of adrenals, adrenal ascorbic acid depletion and higher 17-KS and 17-OHCS levels. These changes disappeared during chronic treatment. It is hence suggested that reserpine through its transistory stimulating effect on the pituitary-adrenal cortex axis acts as a non-specific stimulus, which loses its effect on chronic administration.
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