Active Immunization of Mice Against Candida albicans ∗

Abstract

Summary

Mice were vaccinated by repeated subcutaneous inoculations of living, merthiolate-killed, or sonically-ruptured cells of C. albicans and were then challenged intravenously with 10⁴ or 10⁵ viable particles of a homologous strain. Although not all of the vaccinated mice survived challenge, a significant degree of resistance was conferred since fewer deaths occurred among vaccinated animals.