Abstract
Summary
2-deoxyglucose(2-DG) causes marked release of adrenaline from the adrenal medulla in the intact rat but not after adrenal denervation. The adrenaline released is to a great extent responsible for the hyperglycemia appearing after 2-DG, but other factors might also be involved. The inability of 2-DG to cause increased adrenaline secretion after denervation of the adrenal glands points to its action via a centrally located receptor mechanism regulating adrenaline secretion; this center seems not to be sensitive to the blood glucose level as such.
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