Abstract
Summary
An increased antihypertensive action of a combination of reserpine and acetazolamide over that produced singly by either drug was demonstrated in metacorticoid hypertensive rats. Acetazolamide alone had a moderate antihypertensive action, and the enhanced reduction in blood pressure following co-treatment was an additive rather than a potentiated effect. The typical hypertensive left ventricular cardiac hypertrophy was significantly reduced in the metacorticoid rats receiving acetazolamide-reserpine.
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