Abstract
Summary
1. Simple technics have been described for preparation of 2 new colloids of radioyttrium Y(OH)3 and YPO4. Maltose has been employed as suspending agent for the former, carboxymethylcellulose for the latter. Both products have been demonstrated to have a small, uniform particle size, good emulsion stability, and low percentage dialyzable radioactivity. 2. The LD50 of Y(OH)3 − Y-90 in mice was approximately 12 to 14 mc kg. 3. Tissue deposition in mice and terminal human patients has been predominantly reticulo-endothelial in both. Evidence is suggestive that some metabolic dissociation occurs with subsequent deposition of yttrium in bone. 4. Urinary excretion of activity has been evaluated for mice and man.
Get full access to this article
View all access options for this article.