Abstract
Summary
1. These studies demonstrate that Friend Virus produces in HA/ICR Swiss and DBA/1 mice very soon after infection, a marked increase in selective uptake of Fe59 by the spleen. This selective uptake is not found in other tissues in Friend Virus Disease. 2. Friend Virus Disease characteristically produces a malignant proliferation of splenic reticulum cells, but is further characterized by a progressive elevation of hematocrit and rbc count which is related to splenic involvement in the disease. 3. The DBA/1 strain is shown to be susceptible to Friend Virus to the same magnitude as HA/ICR Swiss mice.
We wish to acknowledge the assistance of Dr. Paul Trudel, André Bulba, Ruth Deckert, Edward Dywinski, Helen Fox and A. G. Mirand.
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