Abstract
Summary
Pretreatment of rabbits with 2 intravenous injections of nitrogen mustard (HN2) partially suppressed production of NDV-induced toxic corneal reactions. In most animals this treatment suppressed development of opacity and reduced markedly the extent of fusions of endothelial cells. It did not inhibit formation of endothelial rosettes. The suppressive effects in the HN2-treated animals lasted for at least 20 days, well after leucopenia had disappeared. Decreased response to injected virus is neither a result of suppression of circulating leucocytes nor of rapid inactivation of virus in aqueous humor.
Treatment of rabbits with a single intravenous injection of HN2 4 days, 2 days, or immediately before virus injection caused no demonstrable suppression of virus-induced toxic reactions of rabbit corneas. Leucocytes appeared to play no essential role in production of corneal reaction.
The authors wish to express their deep gratitude to Dr. C. A. Evans for advice and criticism during this investigation.
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