Abstract
Summary
Mengo infected mouse brain preparations were stable, as judged by mouse lethality, when diluted in 1 molar sodium chloride or distilled water and incubated at 37° C. Mengo virus was inactivated when incubated in 150 mM sodium chloride. Inactivation was directly related to time and temperature of incubation and was demonstrable at concentrations of sodium chloride between 15 and 300 millimolar. Inactivation appeared to be related to the presence of Cl-, or similar anions, rather than Na+.
The author gratefully acknowledges the advice and encouragement of Dr. Chester M. Southam, helpful discussions with Dr. M. Earl Balis, and invaluable assistance of Miss Katherine Aliminosa.
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