Abstract
Summary
Electroshock convulsions were produced in ataxic manganese-deficient rats. The threshold for minimal seizures was significantly lower in the manganese-deficient than in the control animals. During a maximal seizure, duration of the tonic flexor phase was markedly shorter in the deficient than in control rats; duration of the other phases and of postictal depression were similar in both groups. The data are interpreted to mean that brain excitability and convulsability are increased in ataxic manganese-deficient rats; these data may indicate that the brain is involved in the ataxic syndrome characteristic of offspring of manganese-deficient animals.
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