Abstract
Summary
Aconitase and fumarase activity in liver tissue of tularemic rats was demonstrated to be reduced by more than 33% below normal values at height of infection. Administration of cortisone in a concentration of 5 mg per rat per day during infection supported aconitase activity at nearly normal levels for 48 hours but failed to do so beyond that time. Liver fumarase activity of rats treated with cortisone was maintained at only slightly higher levels than observed for the controls. The data presented suggest extensive adrenal involvement in tularemic rats which can be alleviated only partially and temporarily by daily administration of cortisone.
Get full access to this article
View all access options for this article.