Abstract
Summary
The in vitro effect of acetylcholine on adrenocortical secretion of rat adrenals was investigated by direct methods of analysis. ACh increases rat adrenal output of BT reducing substances without corresponding increase in substances measurable by UV regardless of strain of rat or type of ACh derivative used. A relationship between dose and response was observed with ACh doses between 0.01 to 1000 μg/100 mg adrenal. Output achieved with a maximally effective dose of 1000 μg/100 mg adrenal was approximately 1/5 that observed following maximal ACTH stimulation. Specificity of the ACh effect was demonstrated by inhibition with acetylcholinesterase.
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