Abstract
Summary
Duck erythrocytes in vitro take up labeled manganese added to blood. The uptake is mainly ascribable to reticulocytes. Following intravenous administration, the manganese appears promptly in the cells apparently as a function of the readily reversible uptake observed in vitro and as a function of incorporation in bone marrow. Manganese taken up by cells in vivo, but not in vitro, is recoverable to some extent in association with heme. This recovery is considered to support the hypothesis that erythrocyte manganese is present in part at least as a porphyrin complex.
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