Excretion of Urinary N-C 14 -Methyl Morphine and Pulmonary C 14 O 2 in the Monkey and Dog after Subcutaneous Injection of the Labelled Drug. ∗

Abstract

Summary

The results of urinary excretion and C¹⁴O₂ elimination experiments in dogs and monkeys receiving 2.0 mg/kg of N-C¹⁴-methyl morphine, subcutaneously, were as follows: dogs excreted 13–15% of total dose as free morphine and 48–52% as conjugated morphine and about 0.2% as exhaled C¹⁴O_2. Monkeys excreted 6–14% as free morphine and 55–71% as conjugated morphine and about 1% as exhaled C¹⁴O₂.

The authors are indebted to Mr. Salah El-Dareer for his technical assistance in the course of these experiments.