Abstract
Summary
Several chemical analogues and chemically related compounds of Dilantin Sodium have been used to study and clarify the cell stimulatory effects of this compound. Two analogues (1 allyl, 5 phenyl hydantoinate and 5 methyl, 5 phenyl hydantoinate) induce stimulation of fibroblast-like cell proliferation while 2 other analogues (1 propyl, 5 phenyl hydantoinate and 3 methyl, 5,5 diphenyl hydantoinate) were completely ineffective. None of the other structurally related compounds tested (barbital sodium, urea, uric acid, alloxan, allantoin or hydantoin) produced any stimulation of cell proliferation.
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