Abstract
Summary
1. Some of the pathoses of scurvy in guinea pigs were reversed by administration of 3-methylcholanthrene. These included a marked reduction of incidence of hemorrhage, reduction of bone resorption, preservation of dentinogenesis and prevention of death of odontoblasts. 2. The effect 3-methylcholanthrene exerts upon scurvy does not appear to be mediated by induction of L-ascorbic acid synthesis nor by increased retention of the vitamin.
The authors are grateful to Miss C. Mecca for assistance in bioassay experiments and to Miss C. Evans for carrying out the radioactive experiments. Photomicrographs are the courtesy of Mr. John W. McGuire.
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