Abstract
Summary
(1) Liver microsomes from severely diabetic rats incorporate leucine-1-C14 into protein at a lower rate than microsomes from diabetic control rats maintained on insulin. The former have also a lower phospholipid-P and a higher RNA content per unit of protein-N. (2) Microsomes from normal rats incorporate amino acids at a higher rate after injection of insulin. (3) These changes occurred specifically in microsomes; no difference was found with respect to ability of soluble fractions to activate microsomal incorporation. Insulin was without effect upon the microsomal system
Addendum: Korner(17) found amino acid incorporating capacity of liver microsomes from a different type of diabetic rat to be defective.
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