Abstract
Conclusion
Goldthioglucose administration to inbred C57 Black and CBA mice, in amounts sufficient to induce hyperphagia and massive weight gain, results in lesions of nuclei adjacent to the area postrema of the medulla oblongata, to the median eminence of the hypothalamus, to the supraoptic crest between the hypothalamus and the basal telencephalon, and between the subcommissural and subfornical organs associated with the midbrain-epithalamic transition and the hippocampal formation. The hypothesis is advanced that the observed distribution of the lesions is related to deficiency of the blood-brain barrier at these sites.
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