Abstract
Summary
A method for producing a high titer, specific anti-P. tularensis globulin is presented. Roosters immunized with living P. tularensis organisms produced an antiserum that is more specific and has a higher working dilution than rabbit and monkey sera. The suspending medium for the organisms does not affect degree and intensity of specific staining or working dilution of serum. Cross-reactions obtained suggest that a specific antigenic relationship exists between P. tularensis and the Pseudomonas used in this study. This cross-reaction was eliminated by specific adsorption with heterologous living organisms.
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