Abstract
Summary
Studies demonstrate that isopregnenolone-21-carboxylates are potent inhibitors of the renal electrolyte effects of deoxycorticosterone in adrenalectomized rats. Compound III, the most active in the series, was also effective against aldosterone. Available evidence indicates that the compounds affect electrolyte excretion by competition with aldosterone-like steroids at receptor sites in target tissue.
The authors are indebted to Drs. R. R. Burtner, V. A., Drill and B. Riegel for generous advice and helpful criticism in preparation of the manuscript.
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