Abstract
Summary
ACTH produces hypergranulation of the renal juxtaglomerular cells even in absence of pituitary and adrenal glands, and the chronic absence of ACTH depletes juxtaglomerular granules. The renal effect of vasopressin and of hydralazine, substances which produce hypergranulation of juxtaglomerular cells, is blocked by hypophysectomy. These findings support the concept that ACTH mediates many of the responses of the juxtaglomerular cells, and that the juxtaglomerular apparatus is an extra-adrenal site for the direct action of ACTH.
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