Abstract
Summary
Urinary excretion of 5-hydroxyindolacetic acid (5-HIAA) has been evaluated in rats treated with various histamine liberators. Excretion of 5-HIAA was unchanged, even when the liberator was administered repeatedly. When rats were given Compound 48/80 in increasing dosage during 8 days, they were entirely resistant to edema normally produced by other liberators. These animals, however, excreted as much 5-HIAA after injection of reserpine as did the untreated controls. These observations do not militate in favor of a serotonin mediation in development of anaphylactoid edema in rats.
Get full access to this article
View all access options for this article.