Abstract
Summary
In an in vitro test system at pH 7.4 it was found that degradation of serotonin by ceruloplasmin was markedly inhibited by sodium metabisulfite, ascorbic acid, glutathione, BAL, isoniazid, iproniazid, hydralazine, an analog of hydralazine (Ba-20523), isocarboxazid, thiocarbohydrazide, hydrazine hydrate, syrosingopine (Su-3118) and its isomer, Su-5171. Lesser effects were produced by reserpine, tetraethylammonium chloride, and a thiazide diuretic (Su-7075). A number of other sulfhydryl containing, chelating, anti-hypertension, and psychopharmacologic agents were without effect in the test system employed. It was not possible to correlate reaction inhibition with simple presence of sulfhydryl groups, the hydrazine nucleus, or with monoamine oxidase and diamine oxidase inhibition.
The authors wish to express their appreciation to Mrs. Claire Graff and Miss Faye Baldwin for technical assistance during these studies.
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