Abstract
Summary
Under continuous exposure to arsenicals in vitro, mammalian cells showed a remarkably wide range of tolerance to arsenic. To suppress growth of cells by 50% the absolute quantity of arsenic administered as atoxyl was up to 5000 times that in the form of arsenosobenzene. Pentavalent organic arsenicals with nitrogen groups were comparatively well tolerated in cell culture. In cells originating from different tissues and cultured in the same medium, degree of growth inhibition by a particular arsenical was fairly uniform. An adaptation of a DNA assay, useful in estimating cell populations in tissue culture, is described.
Get full access to this article
View all access options for this article.