Abstract
Summary
The hydroxamate of anthranilic acid injected intraperitoneally into rats in a dose of 1.0 mg/g causes anesthesia lasting 10 hours or more. Recovery is apparently complete. One half this dose causes tranquilization and suppression of the conditioned avoidance response. The compound protects mice against twice the lethal dose of strychnine. It merely prolongs the life of animals given metrazol or picrotoxin. A dose of 1.0 g/kg injected intravenously in a dog has no effect on heart rate, EKG or blood pressure and only minor effects on respiration. Equivalent amounts of the hydroxamates of salicylic and benzoic acids have none of the pharmacological effects.
Our thanks are due to Mr. W. J. Novick and Dr. E. M. Scarpelli for assistance in this study.
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