Abstract
Summary
Systemic administration of ThioTEPA caused the development of hyperpigmentation of the ears, tail, and extremities of brown or black mice, but not of mice of lighter coat color or albinos. These changes resulted from increased numbers of dermal and epidermal melanocytes and increased deposition of epidermal melanin. Similar microscopic changes were seen to a lesser degree in the lighter-colored mice, but not in albinos. Gross or microscopic evidence of hyperpigmentation of the general body skin was not found.
Get full access to this article
View all access options for this article.