Adrenal Atrophy and Thyroid Inhibition Following PABA. ∗

Abstract

Summary

The results clarify a previous report(2) in which the possibility of a direct action of PABA on the adrenal gland was suggested as a more likely mechanism for induction of adrenal atrophy by this goitrogen. These data indicate that under conditions where administration of PABA produced adrenal atrophy, inhibition of the thyroid gland occurred as indicated by reduced thyroidal I¹³¹ uptake. Thus further evidence is presented to associate goitrogenic activity with ability to induce adrenal atrophy, though the possibility of a direct action of PABA on the adrenal gland coupled with thyroid inhibition can not be excluded.