Abstract
Summary
1. Highly hormone dependent mammary tumors were induced in rats by a combined treatment of a subthreshold dose of 3-methylcholanthrene and mammotropic hormone(s) (administered by grafts of a functional mammotropic tumor). 2. Growth of these mammary tumors was dependent upon continuation of stimulation by mammotropic hormone(s). 3. Grafts of the mammary tumors remained latent up to 262 days, growing only after mammotropic hormone(s) was administered. 4. Upon resection of mammotropic tumor, a primary mammary tumor promptly and completely regressed; 5 other primary tumors in rats carrying functional mammotropic tumors grew progressively.
The authors acknowledge the technical assistance of Mary Campbell.
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