Abstract
Summary
Studies on the interactions between brucellaphage and Br. abortus, either under extracellular conditions or when the bacteria resided intracellularly within guinea pig mononuclear phagocytes maintained in vitro, showed: 1) inhibitory effects of untreated or UV-treated phage on the multiplication of brucellae, and 2) a lack of such effects in the case of heat-treated phage. These findings suggest an association between brucellacidal, or possibly brucellastatic, effects and phage protein. It was demonstrated that the effects on intracellular bacteria can occur even when exposure to phage is delayed until 2 hours after phagocytosis of the bacteria.
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