Abstract
Summary
A commercially prepared polysaccharide (Piromen) from a species of Pseudomonas inhibited both succinic and cytochrome oxidases of mouse liver mitochondria in vitro. Piromen alters rate of reaction rather than completely suppressing it. Cytochrome oxidase activity seemed to be more sensitive to Piromen than succinoxidase activity. Similar studies utilizing mouse monocytes indicated that succinoxidase activity could be reduced or completely abolished, but cytochrome oxidase activity was relatively insensitive to Piromen inhibition. Inhibition of monocyte succinoxidase activity was proportional to concentration of Piromen used.
The excellent technical assistance of Mr. John Meacham is gratefully acknowledged.
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