Abstract
Summary
The effects of SC-8109, or 3-(3 − oxo − 17β - hydroxy − 19 - nor − 4 - androsten-17α-yl) propanoic acid lactone, and 5 structurally related compounds on atrial arrhythmias were investigated in anesthetized dogs. SC-8109 and 3 other steroidal spirolactones (SC-5233, Aldactone and SC-4988) were approximately equipotent in correcting aconitine-induced arrhythmias. Of these compounds, only SC-4988 did not possess significant DOC-blocking activity in the mammalian kidney. The other 2 compounds in the series, similarly weak as DOC-blockers, were inactive as antiarrhythmic agents. SC-8109 alone reversed the arrhythmia induced by electrical stimulation. DOC and quinidine sulfate were effective against both types of flutter. The relationships of structure-anti-arrhythmic activity and of DOC blocking-antiarrhythmic activities of the steroidal spirolactones are discussed.
The author is indebted to Dr. C. M. Kagawa for many valuable suggestions, to Miss Marlene Shepard for technical assistance, and to Mr. D. W. Calhoun for statistical aid.
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