Abstract
Summary
In normal adult mongrel dogs, radioactive rose bengal dye is rapidly removed from the blood stream with radioactivity reduced 50% in 5 to 10 minutes following intravenous injection of the dye. The liver takes up the dye rapidly, starting within 4 minutes, and excretes it quickly, as evidenced by appearance of dye in the bile 6 minutes after administration. Approximately 20% of the tagged dye passed through the bile in one hour. Urinary excretion is almost negligible, with approximately 0.1% of total dye present in the urine in 60 minutes. Renal, splenic, and pancreatic tissue levels of radioactivity are insignificant and probably represent amount of dye in the blood stream. Radioactivity over the duodenum is evident within the first hour and probably represents amount of dye excreted into the bile.
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