Abstract
Summary
Induction of hyponatremia by intraperitoneal injection of a sodium-free solution resulted in an appreciable fall (13%) in sodium content of rabbit costal cartilage. Induction of hypernatremia by intravenous injection of a sodium-rich solution caused an 11% increase in cartilage sodium content. These changes cannot be accounted for solely in the chloride space of cartilage. About one-half of the change must be ascribed to alterations in that portion of the cartilage sodium which is outside of the chloride space. The observed changes are larger than we have been able to produce in bone.
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