Abstract
Summary
1. Daily administration of DOCA for short periods caused an increased glycogenic response in liver of rats following intraperitoneal injection of glucose. Daily administration of DOCA for longer periods resulted in decreased glycogenic response. 2. DOCA induced inhibition of glycogen formation was accompanied by decrease in potassium content of both liver and blood serum. 3. By forcing an increase in potassium intake, the potassium content of both liver and blood serum was maintained at essentially normal levels and liver glycogen production was not significantly inhibited in rats that received DOCA. 4. These data indicated that DOCA induced inhibition of glycogen formation was secondary to potassium depletion.
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