Evaluation of Renal Function with Radio-Renogram. ∗

Abstract

Conclusions

(1) Routine I¹³¹ diodrast renograms frequently fail to demonstrate significant renal lesions. (2) Initial loading of tubular mechanism responsible for secretion of diodrast by competitive substance (for example, para-amino-hippurate) blocks concentration and secretion of I¹³¹ diodrast. (3) As tubules secrete the competing substance and plasma level gradually returns toward normal, the control kidney in cases of unilateral disease demonstrates, on successive injections of I¹³¹ diodrast, earlier appearance of uptake and secretion as well as greater quantitative uptake and secretion of I¹³¹ diodrast.