Abstract
Summary
In pento-barbitalized dogs, partial clamping of abdominal aorta, always lowered Ck, Cer and CK/Cer. For these changes to occur mean arterial pressure had to fall below 75 mm Hg. Extraction ratio of PAH was not lowered by hypotension. The calculated renal plasma flow was markedly reduced and reactive hyperemia probably did not occur after clamping. The fraction of calculated quantity of K delivered to kidney that was excreted was much less during hypotension. Hypotension, insufficient to lower Cer, markedly lowered Na excretion but not CK. In agreement with Davidson, elevation of rate of Na excretion, reduced the effect of hypotension on CK and allowed CK/Cer to rise above one. The need to consider another factor in addition to urinary Na in the effect of hypotension on K excretion is pointed out.
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