Abstract
Conclusion
In animal species in which T-1824 is firmly bound to the plasma proteins, absorption of dye by the reticulo-endothelial system and other tissues during the “mixing period” is not a significant source of error in measurement of plasma volume with this dye. With T-1824, as well as with other suitable test substances, back-extrapolation of the time concentration curve on a semi-log plot provides satisfactory correction for loss during the mixing period.
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