Abstract
Summary
1) Passive serum sickness was produced in mice using homologous antibodies, obtained from immune ascitic fluid, in the form of soluble antigen-antibody complexes. Lesions were similar to those obtained with rabbit antibody-antigen complexes, but, in addition, amorphous eosinophilic material was seen in many glomerular capillary loops. Incidence and intensity of lesions using homologous antibody was greater than with equal amounts of heterologous rabbit antibody. 2) Homologous antibody was more effective in producing lethal anaphylaxis than rabbit antibody when both were given as soluble complexes.
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