Prevention of Malignant Cell Growth and Spread by Tropical Pretreatment with Radioactive Chromic Phosphate. ∗

Abstract

Summary and conclusions

(1) Pretreatment of new mice with CrP³²O⁴, in well tolerated doses for topical prevention of tumor growth and spread was applied in various topographic areas, i.e., pleural cavity, scalp, abdominal wall and leg. (2) Reduction of tumor growth in all areas and of its spread in pleural and scalp were directly proportional to dose of radioactivity and inversely to the period between isotope injection and tumor inoculation. (3) These findings showed that amount of radioactivity stored in pretreated tissues at time of tumor inoculation was the major factor of the isotope's preventive effect. However, previous results(1) suggested also another effect of pretreatment, that of tissues increased resistance to invasion with tumor cells. (4) It was concluded that topical pretreatment with CrP³²O₄ may be attempted for prevention of postoperative growth and spread of tumor cells.