Abstract
Summary
A series of steroidal spirolactones, of interest for their aldosterone antagonistic actions, were tested as estrogen antagonists in a mouse uterine growth test. The 2 activities did not appear to be correlated. Progestational activity similarly showed no direct relationships. Structural requirements for estrogen antagonistic potency are discussed. SC-8109 and 2 other 19-nor derivatives of SC-5233, 3-(3-oxo-17β-hy-droxy-4-androsten-17α-yl) propionic acid γ-lactone, were estrogen antagonists.
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